(Download) "Remnant-Like Particle-Cholesterol Concentrations in Patients with Type 2 Diabetes Mellitus and End-Stage Renal Disease (Lipids, Lipoproteins, And Cardiovascular Risk Factors)" by Clinical Chemistry # eBook PDF Kindle ePub Free
eBook details
- Title: Remnant-Like Particle-Cholesterol Concentrations in Patients with Type 2 Diabetes Mellitus and End-Stage Renal Disease (Lipids, Lipoproteins, And Cardiovascular Risk Factors)
- Author : Clinical Chemistry
- Release Date : January 01, 2000
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 223 KB
Description
Atherosclerotic cardiovascular disease is the leading cause of death in diabetes, particularly type 2 diabetes, and in patients with end-stage renal disease (ESRD). [4] Dyslipidemia, characterized by hypertriglyceridemia, reduced HDL-cholesterol (HDL-C), and increased LDL-cholesterol (LDL-C), small dense LDL, and lipoprotein(a) may contribute to the accelerated atherosclerosis in these patients (1-4). Accumulating evidence also indicates that remnant lipoproteins promote atherosclerosis. Remnant lipoproteins are products of partially catabolized chylomicrons and VLDL from which some triglycerides (TGs) have been removed by the action of lipoprotein lipase and, to a lesser extent, by hepatic lipase. The resulting chylomicron and VLDL remnants, including intermediate-density lipoprotein (IDL), with reduced TGs but enriched cholesterol and apolipoprotein (apo) E, are smaller in size and more dense, and are believed to be more atherogenic than the larger triglyceride-rich lipoproteins (TRLs) (5-8). Several studies have implicated IDL concentrations with increased incidence or recurrence of coronary artery disease (CAD) (9-12). Increased IDL also has been found in diseases associated with accelerated or premature atherosclerosis, such as type III dyslipidemia, diabetes mellitus, chronic renal failure, and familial hypercholesterolemia (12-16). Ultracentrifugation and nondenaturing polyacrylamide gel electrophoresis methods have been used to separate small VLDL and IDL particles (13-17), but these methods are tedious and time-consuming and hence have limited applicability in clinical laboratories. Thus, development of simple and reliable methods for measurement of remnants for routine clinical laboratories is imperative.